The Virginia Tech Hokies and the No. 18 Purdue Boilermakers square off Wednesday night at Cassell Coliseum in one the marquee matchups of the ACC-Big Ten Challenge (7:30 pm ET, ESPN).

Purdue is ranked 22nd in the latest AP poll and 18th in the ESPN/USA Today poll, while Virginia Tech is unranked but has received votes in both polls.

The Boilermakers are 5-1 straight up and 2-1 against the point spread so far this season. The Hokies are 4-2 SU and 1-4 ATS.

The Boilermakers have not fared well at the ACC-Big Ten Challenge, going 3-6 SU in nine appearances, and have not won a Challenge game on the road. As well, Purdue is 0-3 SU in three previous meetings with the Hokies.

Purdue will be looking to bounce back from its first setback of the season on Saturday, when the Boilermakers lost 65-54 to the Richmond Spiders. Purdue failed to cash as a 6.5-point home favorite and the score stayed under the total of 132.5.

Virginia Tech lost 71-59 to the No. 23 UNLV Rebels in the title game of the 76 Classic on Sunday at the Anaheim Convention Center, failing to cash as a 3.5-point underdog. The score stayed under the total of 138.

The Boilermakers are averaging 80.2 points per game while Hokies are averaging 67.7 PPG.

NCAAB Odds have not yet been posted for this College Basketball matchup.

The Boilermakers are without All-American senior forward Robbie Hummel. Who is out for the season with a torn ACL.

You know the NCAA College Basketball season is in full swing when the ACC/Big Ten Challenge begins.

The annual event, which pits teams from the Atlantic Coast Conference against those from the Big Ten conference, got going Monday and features a slew of ranked teams, including the No. 1 Duke Blue Devils.

On Tuesday, the No. 25 North Carolina Tar Heels take on the No. 19 Illinois Fighting Illini at Assembly Hall (9:30 pm ET, ESPN).

The Tar Heels and Fighting Illini are both 2-2 SU and ATS in the past four head-to-head meetings. Tuesday’s matchup will mark their first clash since Nov. 29, 2005, when the Fighting Illini beat the Tar Heels 68-64. Illinois cashed as a 1-point underdog and the score stayed under the over/under total of 148.5.

North Carolina’s last action was on Sunday when they hosted South Carolina rival the College of Charleston Cougars. The Tar Heels won 74-69 but didn’t come close to cashing as a 13.5-point favorite, and the score was under the total of 156.5.

The Fighting Illini last played on Saturday when they beat the Western Michigan Broncos 78-63 on the road. There was no point spread or total posted.

Illinois was led by senior Mike Tisdale, who scored 18 points on 6-of-12 shooting from the field and also grabbed seven rebounds.

North Carolina is 4-2 SU and 1-3 ATS this season while Illinois is 4-2 SU and 3-3 ATS.

This is the 11th installment of the ACC/Big Ten Challenge, which the Big Ten won last year for the first time after a decade of ACC dominance.

The San Francisco 49ers and the Arizona Cardinals meet on Monday Night Football in a clash of NFC West division rivals at the University of Phoenix Stadium (8:35 pm ET, ESPN).

NFL Week 12 Odds have the 49ers as 1-point, -120 moneyline favorites with the over/under total at 40.

Arizona is 6-4 straight up and 4-5-1 against the point spread in the past 10 head-to-head meetings, but the 49ers are 4-2 SU in the past six. Over/under bettors should note that the total has gone under in four of the past six meetings overall, but has gone over in five of the past six meetings in Phoenix.

The 49ers won both meetings last season. The teams last squared off Dec. 14, when San Francisco beat Arizona 24-9, easily covering as a 4-point home underdog. The score went under the total of 44.5. In the first meeting of the season Sept. 13, the 49ers won 20-16 and cashed as a 4.5-point road dog. That score was also under the total, which was set at 45.

San Francisco (3-7 SU, 4-6 ATS) continued to stumble through the season last week, getting shut out 21-0 by the visiting Tampa Bay Buccaneers. The 49ers failed to cover as 3.5-point home favorites and the score was well below the total.

Arizona (3-7 SU, 3-7 ATS) lost its 5th-straight game, falling 31-13 to the Kansas City Chiefs on the road. The Cardinals failed to cover as a 7-point underdog and the 44 points kept the game under the total.

Two of the hottest teams in the NFL square off Sunday when the Philadelphia Eagles take on the Chicago Bears at Soldier Field (4:15 pm ET, FOX).

Philadelphia is a 3-point favorite and the over/under total is at 42 in NFL Odds.

Both teams enter the game riding three-game winning streaks. And both are at the top of their respective divisions: Philadelphia (7-3 SU and 5-5 ATS) leads the NFC East, while Chicago (7-3 SU and 5-4-1 ATS) shares top spot in the NFC North with the Green Bay Packers.

The Eagles took over first place in the NFC East with a 27-17 win over the New York Giants last Sunday at Lincoln Financial Field. Philly cashed as a 3.5–point home favorite and the score stayed under the over/under total.

The Bears haven’t played since a Thursday night game on Nov. 18, when they shut out the Miami Dolphins on Thursday night football Nov. 18. The Bears covered as a 2.5-point road underdog, and the score stayed well below the total.

Philadelphia has dominated the head-to-head series straight up, with the Eagles at 6-3 SU in the past nine games. The Eagles have been even better at Soldier Field, going 5-1 SU in the past six meetings in Chicago. The Bears have a slight edge ATS at 5-4 ATS in those matchups.

The Eagles and Bears last met in November last season, when Philly won 24-20 and covered the spread as a 3.5-point road favorite. The score went over the total of 40.

Philadelphia is 5-1 SU in its last six games, and the total has gone over in five of Philadelphia’s last six games, both overall and on the road.

The Florida Gators and the No. 22 Florida State Seminoles square off in a big battle of in-state College Football rivals on Saturday at Doak Campbell Stadium (3:30 pm ET, ABC ESPN).

The Seminoles are a 2-point favorite and the over/under total is at 51 in NCAA Football Odds.

The Gators have pretty much owned the head-to-head battle in recent years, going 7-3 SU and 6-4 ATS in the past 10 clashes, including a perfect 5-0 SU in the past five meetings, and 5-1 ATS in the past six. The total has gone under in five of the past six meetings.

In their annual meeting on Nov. 28 last season, the Gators beat the Seminoles 37-10 and covered as a 26-point home favorite. The score went under the total of 57.

Last Saturday, the Gators cruised to a 48-10 rout over the Appalachian State Mountaineers, and covered a big spread as a 24-point favorite. The score went over the over/under total.

Florida State managed a 30-16 victory over ACC Atlantic rival Maryland Terrapins. The Seminoles covered as a 4-point road favorite and the score stayed under the total.

Florida is 7-4 SU, 4-5-1 ATS, 4-4 SEC, and in second place in the SEC East. Florida State is 8-3 SU, 5-5 ATS, 6-2 in the ACC, and in first place in the ACC Atlantic. The Seminoles have won two straight games.

Florida is 15-2 SU in its last 17 games on the road while Florida State is 7-1 SU in its last eight games at home.

There are a lot of big NCAA College Football games on this weekend but perhaps none bigger than the annual Iron Bowl between state and SEC conference rivals the No. 9 Alabama Crimson Tide and the No. 2 Auburn Tigers at Bryant-Denny Stadium on Friday (2:30 pm ET, CBS).

This year’s tilt marks just the second Iron Bowl in 35 years that these fierce rivals have both been ranked in the Top 10, and the first time since 2005 that they’ve both been ranked in the Top 25.

NCAAF Odds have the Crimson Tide as a 4-point, -165 moneyline favorite and the over/under total at 58.5.

Auburn is 7-3 SU and 6-4 ATS in the past 10 meetings head-to-head, and 4-1 SU in the past five meetings at Alabama. The teams last squared off on Nov. 27 last season, when the Tide rolled past the Tigers 26-21 but were unable to cover as a 10-point road favorite. The score stayed under the total of 47.5

Both Auburn and Alabama are coming off bye weeks, with the Tigers beating the Georgia Bulldogs 49-31 in their last game on Nov. 13. Auburn cashed as a 7.5-point favorite and the score went over the total.

Alabama beat the Mississippi State Bulldogs 30-10 two weeks ago, cashing as 13-point favorites. The score stayed well below the total.

The Tigers are 11-0 SU and 7-3 ATS, and 7-0 in the SEC. Alabama is 8-2 SU and 6-4 ATS, 5-2 in the conference.

Alabama is 5-0 SU in its last five games at home, and the total has gone under in five of Alabama’s last five games at home.

NFL bettors have a trio of NFL games on their plate Thursday, as the annual Thanksgiving Classic takes place at three venues.

And as is the tradition, the action kicks off in the Motor City when the Detroit Lions host  Tom Brady and the New England Patriots at Ford Field (12:30 pm ET, CBS).

The Pats are a 6-point favorite and the over/under total is at 50 in NFL Odds.

Head-to-head, New England is 2-1 SU and 1-2 ATS in the past three meetings. The teams last met Dec. 3, 2006, when the Patriots won 28-21 but could not cover the spread as a 13.5-point home favorite.

New England is 8-2 SU and 5-4-1 ATS and Detroit is 2-8 SU and 7-3 ATS this season.

The midday matchup features the Super Bowl champion New Orleans Saints visiting the Dallas Cowboys (4:15 pm ET, FOX).

The Saints are a 4-point favorite and the total is at 50.

New Orleans is 5-1 SU and ATS in the past six meetings. The teams last squared off on Dec. 19 last season, when Dallas beat New Orleans 24-17 and cashed as a 7-point road underdog. The score was under the total of 53.5.

The Thanksgiving Classic finale has the Cincinnati Bengals taking on the New York Jets at Meadowlands Stadium (8:20 pm ET, NFL Network), with the Jets a 9-point favorite and the over/under total at 44.

The teams have met three times in less than a year, as they squared off in a Wild Card game last January, a 24-14 Jets win as a 2.5-point road underdog, and also on the last day of the regular season, when New York blew out the Bengals 37-0 and cashed as a 10-point home favorite.

The Miami Heat battle the Orlando Magic at the Amway Center on Wednesday, the second meeting of the season between the Southeast division rivals (7:30 pm ET, ESPN).

Although it’s early in the 2010-11 NBA season, few would have predicted that the Heat and their Big Three of LeBron James, Dwyane Wade and Chris Bosh would be trailing the Magic in the division standings. But after dropping their past two, Miami is tied with the Atlanta Hawks for second place, both 1.5 games back of the first-place Magic.

Head-to-head, Orlando 6-4 SU in the past 10 head-to-head, and each team is 5-5 against the point spread. The Magic will be looking for revenge after getting blown out by the Heat in their first meeting this season. Miami won 96-70 and cashed as a 3.5-point home favorite on Oct. 29. The score stayed under the over/under total of 188.

The teams split the four-game season series last year, each winning twice and covering twice.

Miami was upset 93-77 by the Indiana Pacers on Monday, failing to cover as a 9-point home favorite. The score was well below the total of 198.

Orlando had a four-game winning streak snapped by the NBA’s hottest team, the San Antonio Spurs, on Monday, losing 106-97. The Spurs cashed as a3.5-point home favorite and the score went over the total of 196.5. Dwight Howard had 26 points and 18 rebounds.

Miami is 8-6 SU and just 5-9 ATS this season while Orlando is 9-4 SU and a worse 4-9 ATS.

Orlando guard Vince Carter is listed as day-to-day with a sore knee. Miami learned Monday that forward Udonis Haslem will be out indefinitely with a torn foot ligament.

As usual, the Los Angeles Lakers are doing it with a dominating offense. The Chicago Bulls, on the other hand, are getting it done with defense.

Something has to give when the Bulls take on the Lakers at the Staples Center in NBA action on Tuesday, with LA looking for its fifth-straight win (10:30 pm ET, NBA TV).

The Lakers are No. 1 in the NBA on offense, averaging 112.5 points per game, and have two players among the top 13 in scoring: Kobe Bryant with 25.6 PPG and Pau Gasol with 22.8 PPG. On their current four-game win streak, they are outscoring opponents by an average of more than 17 points per game.

The Bulls are no offensive slouches, averaging 101.5 PPG, good for 9th in the NBA, but it’s their smothering defense that has helped them win five of their past six. Chicago has held seven of the 11 opponents it’s faced this season to under 100 points, including just 92.7 PPG in the past six.

The Bulls (7-4 SU, 6-4-1 ATS) got a big 88-83 come-from-behind win over the Dallas Mavericks in their last action on Friday, covering as a 5-point road underdog. The score stayed well below the total of 194.

The Lakers (12-2 SU, 9-5 ATS) romped to a 117-89  win over Pacific division rival Golden State Warriors on Sunday. Los Angeles cashed as a 10.5-point home favorite and the score stayed under the total of 218.5.

Gasol had a huge game, netting 28 points on 10-for-10 shooting from the field and 8-for-8 from the free-throw line.

Head-to-head, the Lakers are 8-2 SU and 7-3 ATS in the past 10 meetings, and won both meetings last season.

The San Diego Chargers will try to climb back to .500 when they host AFC West rivals the Denver Broncos on Monday Night Football (8:35 pm ET, ESPN).

According to NFL preseason pundits, the Chargers were going to run away with the AFC West title but instead have played mediocre football all season long and sit at 4-5 SU and ATS, third in the division.

But San Diego has rebounded in its past two games, picking up wins over the Houston Texans and Tennessee Titans. And they can thank quarterback Philip Rivers, who has the NFL’s third-best QB rating at 102.9 and is the No. 1-rated passer with 2,944 yards and 19 touchdowns.

San Diego is a 10-point favorite and the over/under total is at 50.5 in NFL Odds.

San Diego has a slight edge head-to-head at 6-4 SU and 6-2-2 ATS in the past 10. The teams split the season series last year. Denver beat San Diego 34-23 in their first meeting, covering as a 3.5-point road underdog. The Chargers pasted the Broncos 32-3 in the last meeting, cashing as a 6-point road favorite.

Last week, Denver (3-6 SU and ATS, last in the AFC West) beat division co-leader Kansas City Chiefs 49-29, cashing as a 1-point underdog. The score went over the total.

San Diego (4-5 SU and ATS) is coming off its bye week. Two weeks ago, the Chargers beat Houston 29-23 and cashed as a 2.5-point road favorite, with the score over the total.

The total has gone over in six of Denver’s last eight games on the road. San Diego is 8-2 SU in its last 10 at home, and the total has gone over in seven of San Diego’s last nine at home.

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